Catalogue

Background
The p15ink4b tumor suppressor protein shows no cross reactivity with the closely related inhibitors including p16ink4a and p19ink4d. p15ink4b is a specific inhibitor of cdk4/cdk6, and is periodically expressed during cell cycle.

Synonyms: hp15; p15 ink4b; Cyclin-dependent kinase 4 inhibitor B; Multiple tumor suppressor 2

Source
Mice were immunized with a his-tagged recombinant full length p15 protein recognizing a 15kDa protein

Product
Provided as solution in phosphate buffered saline with 0.08% sodium azide

Product Form: Unconjugated

Purification Method: Ammonium Sulfate Precipitation

Concentration: See vial for concentration

Applications
1-5 ug /ml for Western Blot, Immunohistochemistry, and Immunoprecipitation (co-precipitates cdk4/cdk6)

Functional Analysis: Western Blotting

Storage
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Product Stability: See expiration date on vial

Shipping Conditions: Ship at ambient temperature

Caution
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but our company accepts no liability for any inaccuracies or omissions in this information.

References
1) C. Sherr, et.al. (1995) Gene & Dev..9, 1149-1163 2) Sakellariou, S., et al. 'Immunohistochemical Expression of P15 (INK4B) and SMAD4 in Advanced Gastric Cancer.' Anticancer Research (2008), 28, 1079-1083

Protein Reference(s)

Database Name: UniProt

Accession Number: P42772 (Human)

Species Accession: Human

Safety Datasheet(s) for this product: