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Calcium Homeostasis Modulator Protein 1 (CALHM1) (Cat. No. X2410P) - Recently identified gene linked to Alzheimer's disease. CALHM1 encodes a multipass transmembrane glycoprotein that controls cystolic CA(2+) concentrations and Abeta levels. See new article in Cell. Dreses-Werringloer, U., et la. "A Polymorphism in CALHM1 Influences Ca2+ Homeostasis, Ab Levels, and Alzheimer’s Disease Risk." Cell 20008, 133, 1149-1161

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) - Protein which binds to the EGF-A domain of the low density lipoprotein receptor (LDLR) and signals LDLR degradation. This results in decreased LDL metabolism leading to hypercholesterolemia. Two antibodies available, one targeting a function blocking epitope (Cat. No. X2404P) and one which targets a non-blocking epitope (Cat. No. X2403P)

Antibodies to Microphthalmia - clones C5 and D5 - Both clones available alone or together in a cocktail for immunohistochemistry. Both suitable for IHC and detect human microphthalmia protein.

Monoclonal Luciferase antibody, clone Luci17 (Cat. No. X1171M) - An exceptional antibody at a great price….Useful to identify the Luciferase protein used  as a reporter for gene expression studies.  Made to Firefly Luciferase. Works in Western Blot, and IHC. (100µg - $210) Call for multiple vial/bulk pricing

New Product

Sheep anti-human Glypican-3 (GPC3) (Cat. No. X2395P) - Sheep polyclonal antibody to the human GPC3 protein. Antibody recognizes the C-terminal of the GPC3 protein and with an epitope which does not overlap with the 1G12 anti-GPC3 monoclonal currently available on the market. Click link above for product specific page.

BrdU Proliferation Assays/Kits

Assay Kits

Lipid Signaling Family of Products

Flow Cytometry/CD antibodies

CD 56 - the superior CD56 available today.

Neurobiology Product Lines

Including antibodies to:
3-Nitrotyrosine (Cat. No. X1719M) (pdf) - Antibody raised to the nitrotyrosine molecule only, not peroxynitrite-treated proteins. Does not cross-react with S-nitrosothiols.
NGF (neutralizes)
Calcium Channels
Potassium Channels

Wnt Pathway Antibodies including….
LEF (Cat # X1076M binds all LEF isoforms)
TCF3, 4
Beta Catenein

 

UPCOMING MEETINGS

Exalpha will be sponsoring the Glycolipid and Sphingolipid Biology Conference, Feb. 7-12, 2010, in Ventura, CA.

NEW ARTICLES IN LIPID SIGNALING

Valentine, W.J., et al. "Subtype-specific residues involved in ligand activation of the EDG-family lysophosphatidic acid receptors." J. Biol. Chem. 2008 Mar 3; [Epub ahead of print] (Click here for abstract)

Jo, S.K., et al. "Sphingosine-1-phosphate receptors: Biology and therapeutic potential in kidney disease." Kindey Int. 2008 Mar 5; [Epub ahead of printe] (Click here for abstract)

Huwiler, A., et al. "New players on the center stage: Sphingosine 1-phosphate and its receptors as drug targets." Biochem. Pharmacol. 2008 Jan 5; [Epub ahead of print] (Click here for abstract)

Ptasynska, M.M., et al. "Positive feedback between vascular endothelial growth factor-A and autotaxin in ovarian cancer cells." Mol. Cancer Res. 2008, 6(3):352-363. (Click here for abstract)

LOOKING AT PI3 KINASE SIGNALING PATHWAY……

Miled, N., et al. (2007). Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. Science 317:239-242 (Click here for abstract)

Lee, J.Y., et al. (2007). PI3K charges ahead. Science 317:206-207 (Click here for abstract)

Look to Exalpha’s family of products

  • P110 Mouse  Monoclonal Antibody Clone 2G2, Cat #A115M
  • PTEN Sheep Polyclonal Antibody, Cat #D100P

Seluanov, A., et al. "Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat." PNAS (2009) 106(46):19352-19357. (click here for abstract)

(Submit a publishsed paper or poster referencing Exalpha products and we will send you a $100 credit toward your next Exalpha purchase.)

 

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