Exalpha Biologicals, Inc.

NEW ARTICLES IN LIPID SIGNALING

Valentine, W.J., et al. "Subtype-specific residues involved in ligand activation of the EDG-family lysophosphatidic acid receptors." J. Biol. Chem. 2008 Mar 3; [Epub ahead of print] (Click here for abstract)

Jo, S.K., et al. "Sphingosine-1-phosphate receptors: Biology and therapeutic potential in kidney disease." Kindey Int. 2008 Mar 5; [Epub ahead of printe] (Click here for abstract)

Huwiler, A., et al. "New players on the center stage: Sphingosine 1-phosphate and its receptors as drug targets." Biochem. Pharmacol. 2008 Jan 5; [Epub ahead of print] (Click here for abstract)

Ptasynska, M.M., et al. "Positive feedback between vascular endothelial growth factor-A and autotaxin in ovarian cancer cells." Mol. Cancer Res. 2008, 6(3):352-363. (Click here for abstract)

LOOKING AT PI3 KINASE SIGNALING PATHWAY……

Miled, N., et al. (2007). Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. Science 317:239-242 (Click here for abstract)

Lee, J.Y., et al. (2007). PI3K charges ahead. Science 317:206-207 (Click here for abstract)

Look to Exalpha’s family of products

P110 Mouse Monoclonal Antibody Clone 2G2, Cat #A115M
PTEN Sheep Polyclonal Antibody, Cat #D100P

Zhao, Y., et al. "Lipid phosphate phosphatase-1 regulates lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells." Biochem J. 2005, 385:493-502. (click here for abstract)


Search:	• Monoclonal Luciferase antibody, clone Luci17 (Cat. No. X1171M) - An exceptional antibody at a great price….Useful to identify the Luciferase protein used as a reporter for gene expression studies. Made to Firefly Luciferase. Works in Western Blot, and IHC. (100µg - $210) Call for multiple vial/bulk pricing New Product • Sheep anti-human Glypican-3 (GPC3) (Cat. No. X2395P) - Sheep polyclonal antibody to the human GPC3 protein. Antibody recognizes the C-terminal of the GPC3 protein and with an epitope which does not overlap with the 1G12 anti-GPC3 monoclonal currently available on the market. Click link above for product specific page. Products in Development • CALHM1 - Recently identified gene linked to Alzheimer's disease. CALHM1 encodes a multipass transmembrane glycoprotein that controls cystolic CA(2+) concentrations and Abeta levels. See new article in Cell. Dreses-Werringloer, U., et la. "A Polymorphism in CALHM1 Influences Ca2+ Homeostasis, Ab Levels, and Alzheimer’s Disease Risk." Cell 20008, 133, 1149-1161 BrdU Proliferation Assays/Kits • BrdU Colorimetric ELISA • BrdU Chemiluminescent ELISA • BrdU IHC Kit Assay Kits • ApoMark™ DNA Fragmentation Apoptosis Detection Kit • Phospho-ERK1/2 ELISA Kit • Human TNFalpha ELISA Kit Lipid Signaling Family of Products Including antibodies to: • Lass1, Lass2, Lass3, Lass4 & 6 (LAG1 Longevity Assurance Homologs) • Sphingomyelin Phosphodiesterase 3 (nSMase2, Neutral Sphingomyelinase 2) • Neutral Sphingomyelinase Activation Associated Factor (nSMAF) • Ceramide Kinase • Sphingosine Kinase 1 & 2, as well as Sphingosine Kinase 2, Long Form • S1P and LPA Receptors • LPP1, LPP2, LPP3, LPP4 Also, Active Recombinant Enzymes: • Sphingosine Kinase 1 and Sphingosine Kinase 2 • Sphingosine Kinase 2, Long Form • Sphingosine Kinase 1a, Mouse Flow Cytometry/CD antibodies • CD 56 - the superior CD56 available today. Neurobiology Product Lines Including antibodies to: • 3-Nitrotyrosine (Cat. No. X1719M) (pdf) - Antibody raised to the nitrotyrosine molecule only, not peroxynitrite-treated proteins. Does not cross-react with S-nitrosothiols. • NGF (neutralizes) • Calcium Channels • Potassium Channels Wnt Pathway Antibodies including…. • LEF (Cat # X1076M binds all LEF isoforms) • TCF3, 4 • Beta Catenein	NEW ARTICLES IN LIPID SIGNALING Valentine, W.J., et al. "Subtype-specific residues involved in ligand activation of the EDG-family lysophosphatidic acid receptors." J. Biol. Chem. 2008 Mar 3; [Epub ahead of print] (Click here for abstract) Jo, S.K., et al. "Sphingosine-1-phosphate receptors: Biology and therapeutic potential in kidney disease." Kindey Int. 2008 Mar 5; [Epub ahead of printe] (Click here for abstract) Huwiler, A., et al. "New players on the center stage: Sphingosine 1-phosphate and its receptors as drug targets." Biochem. Pharmacol. 2008 Jan 5; [Epub ahead of print] (Click here for abstract) Ptasynska, M.M., et al. "Positive feedback between vascular endothelial growth factor-A and autotaxin in ovarian cancer cells." Mol. Cancer Res. 2008, 6(3):352-363. (Click here for abstract) LOOKING AT PI3 KINASE SIGNALING PATHWAY…… Miled, N., et al. (2007). Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. Science 317:239-242 (Click here for abstract) Lee, J.Y., et al. (2007). PI3K charges ahead. Science 317:206-207 (Click here for abstract) Look to Exalpha’s family of products P110 Mouse Monoclonal Antibody Clone 2G2, Cat #A115M PTEN Sheep Polyclonal Antibody, Cat #D100P Zhao, Y., et al. "Lipid phosphate phosphatase-1 regulates lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells." Biochem J. 2005, 385:493-502. (click here for abstract) (Submit a publishsed paper or poster referencing Exalpha products and we will send you a $100 credit toward your next Exalpha purchase.)