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• Calcium Homeostasis Modulator Protein 1 (CALHM1) (Cat. No. X2410P) - Recently identified gene linked to Alzheimer's disease. CALHM1 encodes a multipass transmembrane glycoprotein that controls cystolic CA(2+) concentrations and Abeta levels. See new article in Cell. Dreses-Werringloer, U., et la. "A Polymorphism in CALHM1 Influences Ca2+ Homeostasis, Ab Levels, and Alzheimer’s Disease Risk." Cell 20008, 133, 1149-1161 • Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) - Protein which binds to the EGF-A domain of the low density lipoprotein receptor (LDLR) and signals LDLR degradation. This results in decreased LDL metabolism leading to hypercholesterolemia. Two antibodies available, one targeting a function blocking epitope (Cat. No. X2404P) and one which targets a non-blocking epitope (Cat. No. X2403P) • Antibodies to Microphthalmia - clones C5 and D5 - Both clones available alone or together in a cocktail for immunohistochemistry. Both suitable for IHC and detect human microphthalmia protein. • Monoclonal Luciferase antibody, clone Luci17 (Cat. No. X1171M) - An exceptional antibody at a great price….Useful to identify the Luciferase protein used as a reporter for gene expression studies. Made to Firefly Luciferase. Works in Western Blot, and IHC. (100µg - $210) Call for multiple vial/bulk pricing New Product • Sheep anti-human Glypican-3 (GPC3) (Cat. No. X2395P) - Sheep polyclonal antibody to the human GPC3 protein. Antibody recognizes the C-terminal of the GPC3 protein and with an epitope which does not overlap with the 1G12 anti-GPC3 monoclonal currently available on the market. Click link above for product specific page. BrdU Proliferation Assays/Kits Assay Kits • ApoMark™ DNA Fragmentation Apoptosis Detection Kit Lipid Signaling Family of Products Including antibodies to: Also, Active Recombinant Enzymes: Flow Cytometry/CD antibodies • CD 56 - the superior CD56 available today. Neurobiology Product Lines Including antibodies to: Wnt Pathway Antibodies including….
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NEW ARTICLES Blaydon, D.C, et al. "Imflammatory Skin and Bowel Disease Linked to ADAM17 Deletion" N Engl J Med, 2011, 365, 1502-1508 (click here for abstract) Jeung, HC, et al. "A randomized phase 2 study of doxetaxel and S-1 versus docetaxel and cisplatin in advanced gastric cancer with an evaluation of SPARC expression for personalized therapy." Cancer, 2011, 117, 2050-2057 (click here for abstract) Seux, M, et al. "TP53INP1 decreases pancreatic cancer cell migration by regulating SPARC expression." Oncogene, 2011, epub ahead of print (click here for abstract) LOOKING AT PI3 KINASE SIGNALING PATHWAY…… Miled, N., et al. (2007). Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. Science 317:239-242 (Click here for abstract) Lee, J.Y., et al. (2007). PI3K charges ahead. Science 317:206-207 (Click here for abstract) Look to Exalpha’s family of products
Seluanov, A., et al. "Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat." PNAS (2009) 106(46):19352-19357. (click here for abstract) (Submit a publishsed paper or poster referencing Exalpha products and we will send you a $100 credit toward your next Exalpha purchase.) |
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© 2010 Exalpha Biologicals
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