PTPIA2 (693-979)
- Product Code: X1774E
- Size: 20 µg
- Availability:
In Stock - Price (USD): $260
Cat #
Data Sheet
Product Name
PTPIA2 (693-979)
Synonyms
Receptor-type tyrosine-protein phosphatase-like N; R-PTP-N; Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTPRN
Host/Source
E.coli
Product Type
Active Enzyme
Reactivity
Human
Applications
Study of enzyme kinetics, regulation, and to dephosphorylate target substrates.
Size
20 µg
Price (USD)
$260
Background
Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2. Interacts with phosphorylated SNTB2, protecting it from protein cleavage by CAPN1. Dephosphorylation of SNTB2 upon insulin stimulation disrupts the interaction and results in its cleavage.
Immunogen
E. Coli
Formulation
Provided in 50 mM Tris-HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 3 mM DTT, 20 mM glutathione.
Customer Storage
Products should be stored at -80°C. Aliquot to avoid freeze/thaw cycles.
Database Links:
| GenBank | 002846 | Human |
References
1. T. Ort et al., EMBO J. 2001, 20: 4013-232. Z. Li et al., J Histochem Chytochem. 2000, 48:761-7