PINK1 (E417G Mutant)
- Product Code: X2778B
- Size: 50 µg
- Availability:
In Stock - Price (USD): $110
Cat #
Data Sheet
Product Name
PINK1 (E417G Mutant)
Synonyms
PTEN-induced putative kinase protein 1
Product Type
Blocking Peptide
Reactivity
Blocking Peptide to Cat # X2763P
Applications
Blocking Peptide
Size
50 µg
Price (USD)
$110
Background
This peptide is the immunogen used to make Cat # X2763P.
Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation. Defects in PINK1 are the cause of Parkinson disease type 6 (PARK6). A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep.
Formulation
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Customer Storage
Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles