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Lass1 (Cross reacts with GDF1) Polyclonal Antibody Catalog Number: X2084P Host Species/Clone: Rabbit Prouct Type: Polyclonal Antibody Isotype: IgG Product Size/Price (US$): 100 µg, $245 Species Reactivity: Human Applications: Western Blot Immunogen: Synthetic peptide derived from the human Lass1 protein. Usage: Antibody can be used for Western blotting (1-5 µg/ml starting dilution). Other uses not yet tested. Only reacts with human Lass1 protein. Also cross reacts with human GDF1. Optimal concentration should be evaluated by serial dilutions. Positive Control: Hypothalamus Description: LAG1 is a longevity gene, the first such gene to be identified. Originally cloned from the yeast Saccharomyces cerevisiae. A close homolog of this gene, LAC1, has been found in the yeast genome. The human homolog of LAG1 has functions in human aging. LAG1 may be involved in neurodegenerative diseases and human aging. Lass1 may be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner. Located in the endoplasmic reticulum membrane; LAss1 is a multi-pass membrane protein. Predicted Molecular Weight: 39536 kDa Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide Storage Conditions: Product should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles Database Links: SwissProt P27544 Human Click link here to download datasheet .pdf file |
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